Hydrochloric Acid → 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

HRID 805600Notes

Reaction equation

HRID 805600 reaction equation
[CH3:24][NH:25][O:26][CH3:27].[CH3:37][N:38]([CH3:39])[CH:40]=[O:41].[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[CH:28]([N:29]([CH2:30][CH3:31])[CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[ClH:23].[NH2:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([Cl:11])[n:10]1.[OH2:12].[OH2:48].[OH:13][n:14]1[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[n:21][n:22]1>>[NH2:1][c:2]1[c:3]([C:4](=[O:5])[N:25]([CH3:24])[O:26][CH3:27])[cH:7][cH:8][c:9]([Cl:11])[n:10]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962Water2×HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 14232N,O-DimethylhydroxylamineHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 122639922-Amino-6-chloronicotinic acid

Product 1

HCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

Sources & evidence

ORD record
ord-2669c604c9d9450faa092f4a43b913e3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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