Hydrochloric Acid → 7'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 806648Notes

Reaction equation

HRID 806648 reaction equation
[CH2:27]([P:28]([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][CH3:36])[CH2:37][CH2:38][CH3:39].[CH3:57][CH2:58][O:59][C:60](=[O:61])[CH3:62].[ClH:56].[N:40]([C:41]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:47])=[N:48][C:49]([O:50][C:51]([CH3:52])([CH3:53])[CH3:54])=[O:55].[OH:1][c:2]1[c:3]([C:11]2([CH2:25][OH:26])[C:12](=[O:24])[NH:13][c:14]3[c:15]([C:20]([F:21])([F:22])[F:23])[cH:16][cH:17][cH:18][c:19]32)[cH:4][c:5]2[c:6]([cH:10]1)[O:7][CH2:8][O:9]2>>[c:2]12[c:3]([cH:4][c:5]3[c:6]([cH:10]1)[O:7][CH2:8][O:9]3)[C:11]1([C:12](=[O:24])[NH:13][c:14]3[c:15]([C:20]([F:21])([F:22])[F:23])[cH:16][cH:17][cH:18][c:19]31)[CH2:25][O:26]2

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 13831TributylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 673564263-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-7-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 685972007'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-3a98251e851c48318c88c10dbcc1578a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…