Chloride → methyl N-[2-fluoro-5-(trimethylsilylethynyl)benzyl]carbamate

HRID 810594Notes

Reaction equation

HRID 810594 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:14])[c:6]([CH2:7][NH:8][C:9]([O:10][CH3:11])=[O:12])[cH:13]1.[CH3:15][Si:16]([CH3:17])([CH3:18])[C:19]#[CH:20].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[Cl-:22].[Cu:23][I:24].[Na+:21]>>[c:2]1([C:20]#[C:19][Si:16]([CH3:15])([CH3:17])[CH3:18])[cH:3][cH:4][c:5]([F:14])[c:6]([CH2:7][NH:8][C:9]([O:10][CH3:11])=[O:12])[cH:13]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 923Sodium ionHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 15483912methyl N-(5-bromo-2-fluorobenzyl)carbamate

Product 1

HCID 15483915methyl N-[2-fluoro-5-(trimethylsilylethynyl)benzyl]carbamate

Sources & evidence

ORD record
ord-ec25e706c77b4bb4b2b66198398f251b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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