Acetic Acid → (4-benzylmorpholin-2-yl)(tetrahydro-2H-pyran-4-yl)methanone

HRID 811157Notes

Reaction equation

HRID 811157 reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:12][O:13][N:14]([C:15](=[O:16])[CH:17]1[O:18][CH2:19][CH2:20][N:21]([CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:22]1)[CH3:30].[CH3:31][C:32](=[O:33])[OH:34].[CH3:9][I:10].[Cl-:35].[Cl:2][CH:3]1[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1.[I:11].[Mg:1].[NH4+:36].[OH2:37]>>[CH:3]1([C:15](=[O:16])[CH:17]2[O:18][CH2:19][CH2:20][N:21]([CH2:23][c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[CH2:22]2)[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1

Participants

11

Reactant 10

HCID 176Acetic AcidHCID 223AmmoniumHCID 312ChlorideHCID 962WaterHCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24841Hydrogen iodideHCID 1372022H-Pyran, 4-chlorotetrahydro-HCID 5462224MagnesiumHCID 597893084-benzyl-N-methoxy-N-methylmorpholine-2-carboxamide

Product 1

HCID 59789303(4-benzylmorpholin-2-yl)(tetrahydro-2H-pyran-4-yl)methanone

Sources & evidence

ORD record
ord-5d0afe0633c2499da05d0c21d0e105d3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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