Hydrochloric Acid → trans-3-[4-(4-methoxycarbonylbutylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)-benzofuran-2-carboxamide

HRID 814300Notes

Reaction equation

HRID 814300 reaction equation
[Br:32][CH2:33][CH2:34][CH2:35][CH2:36][C:37](=[O:38])[O:39][CH3:40].[CH3:52][N:53]([CH3:54])[C:55](=[O:56])[CH3:57].[CH3:58][CH2:59][O:60][C:61](=[O:62])[CH3:63].[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[ClH:1].[ClH:2].[I-:51].[K+:50].[NH2:3][CH:4]1[CH2:5][CH2:6][CH:7]([C:10](=[O:11])[NH:12][c:13]2[c:14]([C:22](=[O:23])[NH:24][c:25]3[n:26][cH:27][c:28]([Cl:31])[cH:29][cH:30]3)[o:15][c:16]3[c:17]2[cH:18][cH:19][cH:20][cH:21]3)[CH2:8][CH2:9]1>>[NH:3]([CH:4]1[CH2:5][CH2:6][CH:7]([C:10](=[O:11])[NH:12][c:13]2[c:14]([C:22](=[O:23])[NH:24][c:25]3[n:26][cH:27][c:28]([Cl:31])[cH:29][cH:30]3)[o:15][c:16]3[c:17]2[cH:18][cH:19][cH:20][cH:21]3)[CH2:8][CH2:9]1)[CH2:33][CH2:34][CH2:35][CH2:36][C:37](=[O:38])[O:39][CH3:40]

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 813Potassium CationHCID 8857Ethyl AcetateHCID 30165Iodide IonHCID 31374DimethylacetamideHCID 79557Methyl 5-bromovalerateHCID 81531DiisopropylethylamineHCID 230625763-[(4-aminocyclohexanecarbonyl)amino]-N-(5-chloro-2-pyridinyl)-1-benzofuran-2-carboxamide

Product 1

HCID 23062556trans-3-[4-(4-methoxycarbonylbutylamino)cyclohexylcarbonylamino]-N-(5-chloropyridin-2-yl)-benzofuran-2-carboxamide

Sources & evidence

ORD record
ord-a66863a6cd7948d78b2d0e8084713174
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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