Hydrochloric Acid → 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-(N-[3-morpholinopropyl]carbamoyl)quinoline

HRID 814367Notes

Reaction equation

HRID 814367 reaction equation
[C:11](=[O:12])([OH:13])[c:14]1[cH:15][c:16]2[c:17]([NH:26][c:27]3[c:28]([F:34])[cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[cH:18][cH:19][n:20][c:21]2[cH:22][c:23]1[O:24][CH3:25].[CH3:36][N:37]([CH3:38])[CH2:39][CH2:40][CH2:41][N:42]=[C:43]=[N:44][CH2:45][CH3:46].[ClH:35].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][NH2:10])[CH2:5][CH2:6]1.[O:47]=[CH:48][N:49]([CH3:50])[CH3:51]>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:12])[c:14]2[cH:15][c:16]3[c:17]([NH:26][c:27]4[c:28]([F:34])[cH:29][c:30]([Cl:33])[cH:31][cH:32]4)[cH:18][cH:19][n:20][c:21]3[cH:22][c:23]2[O:24][CH3:25])[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 61055N-(3-Aminopropyl)morpholineHCID 226466206-Carboxy-4-(4-chloro-2-fluoroanilino)-7-methoxyquinoline

Product 1

HCID 226466504-(4-chloro-2-fluoroanilino)-7-methoxy-6-(N-[3-morpholinopropyl]carbamoyl)quinoline

Sources & evidence

ORD record
ord-b12f892b977840179f11de050aa70805
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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