Triethylamine → 4-(4-(4-Benzylpiperidin-1-yl)but-1-ynyl)aniline

HRID 815048Notes

Reaction equation

HRID 815048 reaction equation
[CH2:1]([CH2:2][C:3]#[CH:4])[N:5]1[CH2:6][CH2:7][CH:8]([CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[CH2:9][CH2:10]1.[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[Cu:33][I:34].[I:18][c:19]1[cH:20][cH:21][c:22]([NH2:23])[cH:24][cH:25]1.[Pd:35]([Cl:36])[Cl:37].[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1.[c:57]1([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[cH:71][cH:72][cH:73][cH:74][cH:75]1>>[CH2:1]([CH2:2][C:3]#[C:4][c:19]1[cH:20][cH:21][c:22]([NH2:23])[cH:24][cH:25]1)[N:5]1[CH2:6][CH2:7][CH:8]([CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[CH2:9][CH2:10]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 108934-IodoanilineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 106093551-(3-Butynyl)-4-benzylpiperidine

Product 1

HCID 107107074-(4-(4-Benzylpiperidin-1-yl)but-1-ynyl)aniline

Sources & evidence

ORD record
ord-b4d7324e2c814cceb79a4b7df8596e68
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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