Methanol → [4-(3-Aminophenyl)-6,7-dimethoxyquinazolin-2-yl]methylamine

HRID 815383Notes

Reaction equation

HRID 815383 reaction equation
[CH3:32][NH2:33].[CH3:34][OH:35].[CH3:36][CH2:37][O:38][C:39](=[O:40])[CH3:41].[CH:28]([OH:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:21][CH3:22])[c:7]([O:19][CH3:20])[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([NH2:18])[cH:15][cH:16][cH:17]2)[n:11]1.[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1>>[c:2]1([CH2:32][NH2:33])[n:3][c:4]2[cH:5][c:6]([O:21][CH3:22])[c:7]([O:19][CH3:20])[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([NH2:18])[cH:15][cH:16][cH:17]2)[n:11]1

Participants

7

Reactant 6

HCID 887MethanolHCID 3776IsopropanolHCID 6329MethylamineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 576095393-(2-Chloro-6,7-dimethoxyquinazolin-4-yl)phenylamine

Product 1

HCID 25196907[4-(3-Aminophenyl)-6,7-dimethoxyquinazolin-2-yl]methylamine

Sources & evidence

ORD record
ord-834518ee1daa40619fe48f104596f53b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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