Hydrochloric Acid → 4-Formyl-3-methylisoxazole-5-carboxylic acid

HRID 817963Notes

Reaction equation

HRID 817963 reaction equation
[CH3:11][c:12]1[n:13][o:14][c:15]([C:17](=[O:18])[OH:19])[cH:16]1.[CH3:27][N:28]([CH3:29])[CH:30]=[O:31].[CH3:6][C:7]([CH3:8])([CH3:9])[NH2:10].[ClH:20].[Li:1][CH2:2][CH2:3][CH2:4][CH3:5].[O:21]1[CH2:22][CH2:25][CH2:24][CH2:23]1.[OH2:26]>>[CH3:11][c:12]1[n:13][o:14][c:15]([C:17](=[O:18])[OH:19])[c:16]1[CH:22]=[O:21].[CH3:6][C:7]([CH3:8])([CH3:9])[NH-:10]

Participants

9

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 6385Tert-ButylamineHCID 8028TetrahydrofuranHCID 8530853-Methylisoxazole-5-carboxylic acidHCID 178418339Butyllithium

Product 2

HCID 197652694-Formyl-3-methylisoxazole-5-carboxylic acidHCID 20624633t-Butylamide

Sources & evidence

ORD record
ord-b8228feded794ede8c075388c628b04e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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