Hydrochloric Acid → 2-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

HRID 824772Notes

Reaction equation

HRID 824772 reaction equation
[C:28]([CH:29]=[CH:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)(=[O:37])[Cl:38].[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[ClH:6].[N:7]1([c:13]2[n:14][c:15]3[cH:16][c:17]([O:26][CH3:27])[c:18]([O:24][CH3:25])[cH:19][c:20]3[c:21]([NH2:23])[n:22]2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1.[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:7]1([c:13]2[n:14][c:15]3[cH:16][c:17]([O:26][CH3:27])[c:18]([O:24][CH3:25])[cH:19][c:20]3[c:21]([NH2:23])[n:22]2)[CH2:8][CH2:9][N:10]([C:28]([CH:29]=[CH:30][c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)=[O:37])[CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 660233-Phenylprop-2-enoyl chlorideHCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

Product 1

HCID 30540822-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

Sources & evidence

ORD record
ord-1cd0d30ee88a488495c7ae905a24273d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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