4-Bromotoluene → 2-Pyridinecarboxylic acid, 3-(4-methylbenzoyl)-

HRID 827775Notes

Reaction equation

HRID 827775 reaction equation
[Br:3][c:4]1[cH:5][cH:6][c:7]([CH3:10])[cH:8][cH:9]1.[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[I:1].[Mg:2].[n:11]1[c:12]2[c:13]([cH:14][cH:15][cH:16]1)[C:17](=[O:18])[O:19][C:20]2=[O:21]>>[c:4]1([C:17]([c:13]2[c:12]([C:20]([OH:19])=[O:21])[n:11][cH:16][cH:15][cH:14]2)=[O:18])[cH:5][cH:6][c:7]([CH3:10])[cH:8][cH:9]1

Participants

6

Reactant 5

HCID 78054-BromotolueneHCID 8028TetrahydrofuranHCID 24841Hydrogen iodideHCID 69688Furo[3,4-b]pyridine-5,7-dioneHCID 5462224Magnesium

Product 1

HCID 103319012-Pyridinecarboxylic acid, 3-(4-methylbenzoyl)-

Sources & evidence

ORD record
ord-ebf3af66cf6f438fa2328d952c30dd18
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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