Tetrahydrofuran → N-[2-[Cyclopropyl[(2-nitrophenyl)sulfonyl]amino]ethyl]-tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

HRID 831214Notes

Reaction equation

HRID 831214 reaction equation
[CH3:69][CH2:70][O:71][C:72](=[O:73])[CH3:74].[CH:20]([N:21]([CH:22]([CH3:23])[CH3:24])[CH2:25][CH3:26])([CH3:27])[CH3:28].[Cl:29][C:30](=[O:31])[O:32][c:33]1[cH:34][cH:35][c:36]([N+:37]([O-:38])=[O:39])[cH:40][cH:41]1.[NH2:1][CH2:2][CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]1[c:9]([N+:14](=[O:15])[O-:16])[cH:10][cH:11][cH:12][cH:13]1)[CH:17]1[CH2:18][CH2:19]1.[O:64]1[CH2:65][CH2:66][CH2:67][CH2:68]1.[c:42]1([C:48]2([c:58]3[cH:59][cH:60][cH:61][cH:62][cH:63]3)[O:49][C:50](=[O:57])[N:51]3[CH:52]2[CH2:53][NH:54][CH2:55][CH2:56]3)[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[NH:1]([CH2:2][CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]1[c:9]([N+:14](=[O:15])[O-:16])[cH:10][cH:11][cH:12][cH:13]1)[CH:17]1[CH2:18][CH2:19]1)[C:30](=[O:31])[N:54]1[CH2:53][CH:52]2[C:48]([c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)([c:58]3[cH:59][cH:60][cH:61][cH:62][cH:63]3)[O:49][C:50](=[O:57])[N:51]2[CH2:56][CH2:55]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 23121868N-(2-aminoethyl)-N-cyclopropyl-2-nitrobenzenesulfonamideHCID 231218811,1-Diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one

Product 1

HCID 23122026N-[2-[Cyclopropyl[(2-nitrophenyl)sulfonyl]amino]ethyl]-tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

Sources & evidence

ORD record
ord-ed98d86bf5464c97b7cb07f2d53973b5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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