Tetrahydrofuran → (+)-N-[5-Cycloheptyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'[3-(N-methyl-N'-piperazinyl)phenyl]urea

HRID 831961Notes

Reaction equation

HRID 831961 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[Cl:15][C:16]([Cl:17])([O:18][C:19]([O:20][C:21]([Cl:22])([Cl:23])[Cl:24])=[O:25])[Cl:26].[NH2:1][c:2]1[cH:3][c:4]([N:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)[cH:5][cH:6][cH:7]1.[NH2:34][CH:35]1[C:36](=[O:54])[N:37]([CH3:53])[c:38]2[c:39]([cH:49][cH:50][cH:51][cH:52]2)[C:40]([CH:42]2[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2)=[N:41]1.[O:55]1[CH2:56][CH2:57][CH2:58][CH2:59]1>>[NH:1]([c:2]1[cH:3][c:4]([N:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)[cH:5][cH:6][cH:7]1)[C:19](=[O:25])[NH:34][CH:35]1[C:36](=[O:54])[N:37]([CH3:53])[c:38]2[c:39]([cH:49][cH:50][cH:51][cH:52]2)[C:40]([CH:42]2[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2)=[N:41]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 94429TriphosgeneHCID 115646133-(4-Methylpiperazin-1-yl)anilineHCID 214804643-amino-5-cycloheptyl-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

Product 1

HCID 15840131(+)-N-[5-Cycloheptyl-2,3-dihydro-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]N'[3-(N-methyl-N'-piperazinyl)phenyl]urea

Sources & evidence

ORD record
ord-88ed5fdf3e484fa6b02aff26497fd8de
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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