Tetrahydrofuran → N-[3-(7-chloro-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl)-4-methylphenyl]-3-trifluoromethylbenzamide

HRID 833650Notes

Reaction equation

HRID 833650 reaction equation
[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[Cl:1][c:2]1[n:3][cH:4][c:5]([CH2:10][NH:11][c:12]2[cH:13][c:14]([NH:19][C:20]([c:21]3[cH:22][c:23]([C:27]([F:28])([F:29])[F:30])[cH:24][cH:25][cH:26]3)=[O:31])[cH:15][cH:16][c:17]2[CH3:18])[c:6]([NH:8][CH3:9])[n:7]1.[Cl:39][C:40]([Cl:41])([O:42][C:43](=[O:44])[O:45][C:46]([Cl:47])([Cl:48])[Cl:49])[Cl:50]>>[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[NH:8][C:9](=[O:42])[N:11]([c:12]1[cH:13][c:14]([NH:19][C:20]([c:21]3[cH:22][c:23]([C:27]([F:28])([F:29])[F:30])[cH:24][cH:25][cH:26]3)=[O:31])[cH:15][cH:16][c:17]1[CH3:18])[CH2:10]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 94429TriphosgeneHCID 86600918N-{3-[(2-chloro-4-methylaminopyrimidin-5-ylmethyl)amino]-4-methylphenyl}-3-trifluoromethylbenzamide

Product 1

HCID 86600919N-[3-(7-chloro-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl)-4-methylphenyl]-3-trifluoromethylbenzamide

Sources & evidence

ORD record
ord-9897e4488e97498191e4b43f45930038
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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