Acetate → 3-(4-Hydroxymethylphenyl)acrylic acid ethyl ester

HRID 833769Notes

Reaction equation

HRID 833769 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][OH:7])[cH:8][cH:9]1.[C:36]([CH:37]=[CH2:38])(=[O:39])[O:40][CH2:41][CH3:42].[C:43]([O-:44])(=[O:45])[CH3:46].[C:48]([O-:49])(=[O:50])[CH3:51].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Pd+2:47].[c:10]1([P:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[c:2]1([CH:38]=[CH:37][C:36](=[O:39])[O:40][CH2:41][CH3:42])[cH:3][cH:4][c:5]([CH2:6][OH:7])[cH:8][cH:9]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 11776TriphenylphosphineHCID 701194-Bromobenzyl alcoholHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

Product 1

HCID 684575823-(4-Hydroxymethylphenyl)acrylic acid ethyl ester

Sources & evidence

ORD record
ord-133573da4e154cbab503a0b0169c2b3a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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