Diisopropylamine → Thiazole, 2-[(trimethylsilyl)ethynyl]-

HRID 834046Notes

Reaction equation

HRID 834046 reaction equation
[CH3:14][Si:15]([CH3:16])([CH3:17])[C:18]#[CH:19].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cu:20][I:21].[I:8][c:9]1[s:10][cH:11][cH:12][n:13]1.[O:63]1[CH2:64][CH2:65][CH2:66][CH2:67]1.[Pd:22]([Cl:23])[Cl:24].[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1.[c:44]1([P:45]([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[cH:58][cH:59][cH:60][cH:61][cH:62]1>>[c:9]1([C:19]#[C:18][Si:15]([CH3:14])([CH3:16])[CH3:17])[s:10][cH:11][cH:12][n:13]1

Participants

8

Reactant 7

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 108675632-Iodothiazole

Product 1

HCID 11622446Thiazole, 2-[(trimethylsilyl)ethynyl]-

Sources & evidence

ORD record
ord-4a4d6eae8cc14b17a6724f3308b9755e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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