Hydrochloric Acid → Methyl 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylate
Reaction equation
[CH3:81][CH2:82][O:83][C:84](=[O:85])[CH3:86].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:22][c:23]1[c:24](-[c:32]2[cH:33][c:34]3[c:35]([n:36][cH:37]2)[o:38][c:39](-[c:45]2[cH:46][cH:47][c:48]([F:51])[cH:49][cH:50]2)[c:40]3[C:41](=[O:42])[O:43][CH3:44])[cH:25][c:26]([C:27](=[O:28])[OH:29])[cH:30][cH:31]1.[ClH:10].[ClH:11].[O:76]=[CH:77][N:78]([CH3:79])[CH3:80].[P-:52]([F:53])([F:54])([F:55])([F:56])([F:57])[F:58].[n:12]1[c:13]([C:18]2([NH2:21])[CH2:19][CH2:20]2)[cH:14][cH:15][cH:16][cH:17]1.[n:59]1([O:60][C:61]([N:62]([CH3:63])[CH3:64])=[N+:65]([CH3:66])[CH3:67])[c:68]2[n:69][cH:70][cH:71][cH:72][c:73]2[n:74][n:75]1>>[n:12]1[c:13]([C:18]2([NH:21][C:27]([c:26]3[cH:25][c:24](-[c:32]4[cH:33][c:34]5[c:35]([n:36][cH:37]4)[o:38][c:39](-[c:45]4[cH:46][cH:47][c:48]([F:51])[cH:49][cH:50]4)[c:40]5[C:41](=[O:42])[O:43][CH3:44])[c:23]([Cl:22])[cH:31][cH:30]3)=[O:28])[CH2:19][CH2:20]2)[cH:14][cH:15][cH:16][cH:17]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid2×
HCID 6228Dimethylformamide
HCID 8857Ethyl Acetate
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 111054091-(Pyridin-2-yl)cyclopropanamine
HCID 672177944-Chloro-3-(2-(4-fluorophenyl)-3-(methoxycarbonyl)furo[2,3-b]pyridin-5-yl)benzoic acidProduct 1
Sources & evidence
- ORD record
- ord-3d798d8fdcab4947b57e110b13b734e1
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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