Ammonium → 1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one

HRID 838604Notes

Reaction equation

HRID 838604 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl-:30].[F:13][c:14]1[cH:15][cH:16][c:17]([Br:20])[cH:18][cH:19]1.[F:21][C:22]([C:23](=[O:24])[O:25][CH2:26][CH3:27])([F:28])[F:29].[NH4+:31]>>[F:13][c:14]1[cH:15][cH:16][c:17]([Br:20])[cH:18][c:19]1[C:23]([C:22]([F:21])([F:28])[F:29])=[O:24]

Participants

9

Reactant 8

HCID 223AmmoniumHCID 312ChlorideHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 9794Ethyl trifluoroacetateHCID 99931-Bromo-4-fluorobenzeneHCID 178418339Butyllithium

Product 1

HCID 113692661-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one

Sources & evidence

ORD record
ord-34b0f6dbe875461eaff43b4e10e26c23
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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