Water → 4-(4-Chlorophenoxy)-3-nitroaniline

HRID 840724Notes

Reaction equation

HRID 840724 reaction equation
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1.F[C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24].O>CN(C=O)C>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][C:16]2[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][C:17]=2[N+:23]([O-:25])=[O:24])=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 962WaterHCID 46844-ChlorophenolHCID 11430Potassium CarbonateHCID 677684-Fluoro-3-nitroaniline

Product 1

HCID 155801494-(4-Chlorophenoxy)-3-nitroaniline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.4 g of potassium carbonate were added to a solution of 1.29 g of 4-chlorophenol in 8 ml of DMF and, after stirring for 30 minutes, 1.6 g of 4-fluoro-3-nitroaniline were added, and the mixture was stirred at 100° C. for 3 hours. After cooling, 80 ml of water were added and, after brief stirring, the precipitate was filtered off with suction and dried in vacuo at 40° C.

Workup

  1. stirringthe mixture was stirred at 100° C. for 3 hours
  2. temperatureAfter cooling
  3. filtrationafter brief stirring, the precipitate was filtered off with suction
  4. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-2d2d4a3caa8e4672b35ef0db46ad0d4c
Source dataset
uspto-grants-2002_04
Patent number
US06369088B2

Reaction notes

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