反应详情

温度

0 °C

To a solution of N,N'-dimethylhydrazine dihydrochloride (1.33 g) and triethylamine (2.02 g) in dry tetrahydrofuran (20 ml) which was cooled to 0° C., was added isopropyl isocyanate (851 mg). The mixture was stirred at 0° C. for 2 hours. After evaporation of the solvent, the residue was dissolved in ethyl acetate (50 ml). The solution was washed with 1 M sodium bicarbonate solution and water successively, and dried over magnesium sulfate. The solvent was evaporated to give N-(isopropylcarbamoyl)-N,N'-dimethylhydrazine (771 mg) as an oil.

1. customAfter evaporation of the solvent
2. dissolutionthe residue was dissolved in ethyl acetate (50 ml)
3. washThe solution was washed with 1 M sodium bicarbonate solution and water successively
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated