Dimethylcarbamoyl Chloride → HCID 20566558, compound

HRID 848232Notes

Reaction equation

HRID 848232 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH3:7][N:8]([CH3:12])[C:9](Cl)=[O:10].Cl.[CH2:14]([S:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][C:24]=1[Cl:30])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CN(C=O)C>[CH3:7][N:8]([CH3:12])[C:9]([NH:29][C:26]1[CH:27]=[CH:28][C:23]([S:22][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:24]([Cl:30])[CH:25]=1)=[O:10]

Participants

5

Reactant 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 11430Potassium CarbonateHCID 1294211280019-85-8

Product 1

HCID 20566558HCID 20566558, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

Anhydrous potassium carbonate (10 g) and dimethylcarbamyl chloride (4.0 g; 0.037 mol) are added to a solution of 2-chloro-4-aminophenyl phenethyl sulfide hydrochloride (3.0 g; 0.01 mol) in dry DMF (75 ml) at 25° C. The reaction mixture is heated at 60° C. for 15 hours and then poured into ice water (500 ml). The precipitate (74%) of title product, a white solid, m.p. 133°-134° C.

Sources & evidence

ORD record
ord-54e8af8c8db544ef82b9b7feed1fc6f0
Source dataset
uspto-grants-1981_10
Patent number
US04294986

Reaction notes

Loading…