Sodium Iodide → HCID 54074435, compound

HRID 851649Notes

Reaction equation

HRID 851649 reaction equation
[H-].[Na+].[Cl:3][C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[O:9])=[CH:6][CH:5]=1.[CH3:20][O:21][C:22](=[O:31])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]Br.[I-].[Na+]>CN(C)C=O>[CH3:20][O:21][C:22](=[O:31])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][N:10]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:8](=[O:9])[C:7]1[CH:18]=[CH:19][C:4]([Cl:3])=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 24758Sodium hydrideHCID 2374784,4'-DichlorobenzanilideHCID 11107373Methyl 8-bromooctanoate

Product 1

HCID 54074435HCID 54074435, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

As described in example 1(a), 2.4 g (0.1 mol) of sodium hydride, 25.2 g (0.1 mol) of 4-chloro-N-(4-chlorophenyl)-benzamid, 200 ml dimethylformamide, 23.7 g (0.1 mol) of 8-bromocaprylic acid methyl ester and 3 g (0.02 mol) of sodium iodide are reacted. Reaction time: 5.5 hours; reaction temperature: 110° C. The crude product is used in the next step without any further purification.

Workup

  1. customare reacted
  2. customReaction time
  3. custom5.5 hours
  4. customreaction temperature
  5. custom110° C
  6. customThe crude product is used in the next step without any further purification

Sources & evidence

ORD record
ord-ecb6df33830e49f998c07e16388c2ae8
Source dataset
uspto-grants-1983_05
Patent number
US04386031

Reaction notes

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