p-Bromoacetophenone → 4-(4-Methyl-1-piperazinyl)acetophenone

HRID 854474Notes

Reaction equation

HRID 854474 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](Br)=[CH:6][CH:5]=1)=[O:3].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+]>[Cu].[Cu](I)I>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:7]2[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[CH:5][CH:6]=2)[CH2:14][CH2:13]1

Participants

6

Reactant 3

HCID 7466p-BromoacetophenoneHCID 11430Potassium CarbonateHCID 531671-Methylpiperazine

Product 1

HCID 335514-(4-Methyl-1-piperazinyl)acetophenoneYield 82%

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 83717Copper iodideCatalyst

Procedure

In a procedure identical to Example 53, 4-bromoacetophenone was reacted with N-methylpiperazine in the presence of potassium carbonate, copper and copper iodide to furnish the desired product in 82% yield.

Sources & evidence

ORD record
ord-c0d710e44bb144d3b2459dc1d82cf1eb
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

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