Hydrochloric Acid → HCID 10195159, compound

HRID 854561Notes

Reaction equation

HRID 854561 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[S:19][C:18]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)=[N:17][C:16]=2[CH2:30][CH3:31])=[C:9]([CH3:32])[CH:8]=1)C.[Li+].[OH-].Cl>C1COCC1>[CH2:30]([C:16]1[N:17]=[C:18]([C:20]2[CH:21]=[CH:22][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:25]=2)[S:19][C:15]=1[CH2:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:33])=[O:3])=[CH:8][C:9]=1[CH3:32])[CH3:31]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 69469735HCID 69469735, compound

Product 1

HCID 10195159HCID 10195159, compoundYield 106.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of {4-[4-Ethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-3-methyl-phenoxy}-acetic acid ethyl ester (80 mg) in THF (1 mL) is added LiOH (1.0 M, 1.0 mL), after 1 hr, acidified by 5 N HCl and extracted with ethyl, dried over sodium sulfate. Concentration gave the title acid compound (80 mg). MS (ES): 452.03 (M++1), the structure is also confirmed by proton NMR.

Workup

  1. extractionextracted with ethyl
  2. dry with materialdried over sodium sulfate
  3. concentrationConcentration

Sources & evidence

ORD record
ord-c0ab9ef2bc3e473d8276cbc6a94daf8e
Source dataset
uspto-grants-2007_08
Patent number
US07259175B2

Reaction notes

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