Toluene → HCID 53707560, compound

HRID 868365Notes

Reaction equation

HRID 868365 reaction equation
[SiH4].[CH2:2]([O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12])[CH2:3][CH2:4][CH3:5].C(OCC)(=[O:15])C.[C:19]1([CH3:25])C=CC=C[CH:20]=1>>[CH2:25]([O:12][CH:11]([OH:15])[CH2:10][O:9][CH2:8][CH2:7][O:6][CH2:2][CH2:3][CH2:4][CH3:5])[CH:19]=[CH2:20]

Participants

5

Reactant 4

HCID 1140Toluene3×HCID 8177Diethylene Glycol Monobutyl EtherHCID 8857Ethyl Acetate2×HCID 23953Silane

Product 1

HCID 53707560HCID 53707560, compoundYield 60%

Procedure

All procedures were the same as for preparation of compound 1 except that diethylene glycol monobutyl ether (45.3 mL, 260 mmoles) was used. After filtering the sodium bromide precipitate and concentrating the filtrate, the product was chromatographed on silica gel (eluents: toluene, 2.5% ethyl acetate in toluene, then 5% ethyl acetate in toluene), to produce a 60% yield of colorless liquid.

Workup

  1. filtrationAfter filtering the sodium bromide precipitate
  2. concentrationconcentrating the filtrate
  3. customthe product was chromatographed on silica gel (eluents

Sources & evidence

ORD record
ord-ae0e9e98eeb94ee1bf4d93dbda0803db
Source dataset
uspto-grants-1988_10
Patent number
US04778909

Reaction notes

Loading…