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HRID870081

反应详情

EQUATION

反应方程式

HRID 870081 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：NOC1CCCCO1
HCID5142091

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

C5H11NO2

结构：O=C(O)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3ccccc3)cc2)c1
HCID66646147

未命名化合物

2 次

PRODUCTS

生成物

1
结构：O=C(/C=C/c1ccn(S(=O)(=O)c2ccc(-c3ccccc3)cc2)c1)NOC1CCCCO1
HCID86613975

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

4
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

结构：O
溶剂HCID962

Water

H2O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Starting materials: (E)-3-[1-(biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid (compound 62) (0.300 g), HOBt?H2O (0.130 g), triethylamine (668 μl), DMF (20 ml), EDC?HCl (0.508 g), O-(tetrahydro-2H-pyran-yl)hydroxylamine (0.089 g). Reaction conditions: room temperature, 1 hour; room temperature, 18 hours.

WORKUP

后处理

  1. customReaction conditions
  2. customroom temperature, 1 hour
  3. customroom temperature, 18 hours