Sodium hydride → HCID 71243824, compound

HRID 873180Notes

Reaction equation

HRID 873180 reaction equation
[H-].[Na+].[OH:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9].Cl[C:14]1[CH:15]=[C:16]2[N:23]([CH:24]([CH3:26])[CH3:25])[CH2:22][CH2:21][N:17]2[C:18](=[O:20])[N:19]=1>C1COCC1.CN(C=O)C>[CH:24]([N:23]1[C:16]2[N:17]([C:18](=[O:20])[N:19]=[C:14]([O:3][CH2:4][C:5]3[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=3)[C:8]#[N:9])[CH:15]=2)[CH2:21][CH2:22]1)([CH3:26])[CH3:25]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 27346773-(Hydroxymethyl)benzonitrileHCID 86724162HCID 86724162, compound

Product 1

HCID 71243824HCID 71243824, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared in a manner similar to that described for E1 using sodium hydride (17.97 mg, 0.449 mmol) in THF (4 mL), 3-(hydroxymethyl)benzonitrile (59.8 mg, 0.449 mmol) and 7-chloro-1-isopropyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one (80 mg, 0.374 mmol) in DMF (2.00 mL).

Workup

  1. customPrepared in a manner similar to

Sources & evidence

ORD record
ord-e63d4fce260d4f129500d0572f3e8fb4
Source dataset
uspto-grants-2015_03
Patent number
US08975400B2

Reaction notes

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