反应详情

5-Phenoxy-2-hydroxybenzaldehyde (20 g, 94 mmol) and potassium carbonate (26.1 g, 188 mmol) are taken up in DMF (250 mL) and treated with benzyl bromide (16.1 g, 94 mmol). The mixture is stirred at room temperature overnight. The mixture is diluted with ethyl acetate and washed three times with saturated aqueous ammonium chloride, dried over magnesium sulfate and evaporated to give 2-benzyloxy-5-phenoxybenzaldehyde as a colorless solid. This is used without further purification.

1. washwashed three times with saturated aqueous ammonium chloride
2. dry with materialdried over magnesium sulfate
3. customevaporated