Hydrochloric Acid → HCID 10120111, compound

HRID 896670Notes

Reaction equation

HRID 896670 reaction equation
C[O:2][C:3](=[O:39])[CH:4]([C:29]1[CH:34]=[CH:33][C:32]([S:35]([CH3:38])(=[O:37])=[O:36])=[CH:31][CH:30]=1)[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[CH:13]=[C:14]([C:22]([S:25]([CH3:28])(=[O:27])=[O:26])([CH3:24])[CH3:23])[CH:15]=[C:16]3[C:21]=2[N:20]=[CH:19][CH:18]=[CH:17]3)[CH:7]=1.[Li+].[OH-].Cl>C1COCC1.CO.O.C(OCC)(=O)C>[CH3:28][S:25]([C:22]([C:14]1[CH:15]=[C:16]2[C:21](=[C:12]([C:8]3[CH:7]=[C:6]([CH2:5][CH:4]([C:29]4[CH:30]=[CH:31][C:32]([S:35]([CH3:38])(=[O:36])=[O:37])=[CH:33][CH:34]=4)[C:3]([OH:39])=[O:2])[CH:11]=[CH:10][CH:9]=3)[CH:13]=1)[N:20]=[CH:19][CH:18]=[CH:17]2)([CH3:24])[CH3:23])(=[O:26])=[O:27]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 10281325HCID 10281325, compound

Product 1

HCID 10120111HCID 10120111, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 21892291Methanol tetrahydrofuran waterSolvent

Conditions

Temperature
21 °C

Procedure

To a solution of Example 7 (130 mg, 0.23 mmol) in THF/MeOH/H2O (2:2:1, 5 mL) was added LiOH (2M, 0.35 mL, 0.69 mmol). The resulting mixture was stirred at 21° C. 18 h, acidified with HCl 10% and diluted with ethyl acetate. The organic extracts were washed (H2O), (brine), dried (MgSO4), filtered and concentrated. The title compound was obtained as a white powder after sonication in ether/hexane and filtration.

Workup

  1. custom18 h
  2. washThe organic extracts were washed (H2O), (brine),
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f8b09e72172643edbbf7a5511f9b24bf
Source dataset
uspto-grants-2005_07
Patent number
US06919353B2

Reaction notes

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