Hydrochloric Acid → HCID 69112412, compound

HRID 900258Notes

Reaction equation

HRID 900258 reaction equation
C[O:2][C:3]([C:5]1[NH:6][C:7]([CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH3:18])=[N:8][CH:9]=1)=[O:4].O.[OH-].[Li+].Cl>C1COCC1.O>[CH3:18][O:17][CH2:16][CH2:15][O:14][CH2:13][CH2:12][O:11][CH2:10][C:7]1[NH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][N:8]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 69112512HCID 69112512, compound

Product 1

HCID 69112412HCID 69112412, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

2-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-3H-imidazole-4-carboxylic acid methyl ester (460 mg) and lithium hydroxide monohydrate (450 mg) in THF (3 mL) and water (1 mL) were stirred at 58° C. for 10 h. After cooling the mixture was carefully neutralized by the addition of 2 N HCl and concentrated to give crude 2-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-3H-imidazole-4-carboxylic acid. Yield: 905 mg.

Workup

  1. temperatureAfter cooling the mixture
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-23e01bd0d36d44a2bf192fa2d56ea35a
Source dataset
uspto-grants-2008_04
Patent number
US07358268B2

Reaction notes

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