反应详情

Triethylamine (2.0 ml) and benzyl bromide (1.2 ml) were added to a solution of 3-oxocyclobutanecarboxylic acid (J. Org. Chem., Vol. 53, pp. 3841-3843, 1981) (995 mg) in tetrahydrofuran (5.0 ml), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with ethyl acetate, and washed successively with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and saturated saline and dried over anhydrous sodium sulfate. The solvent was then distilled off under reduced pressure, and the resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:6) to obtain the title compound (886 mg).

1. washwashed successively with 1N hydrochloric acid
2. dry with materiala saturated aqueous solution of sodium hydrogencarbonate and saturated saline and dried over anhydrous sodium sulfate
3. distillationThe solvent was then distilled off under reduced pressure
4. customthe resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:6)