1,2-Dichloroethane → N-(2,3-dihydro-1H-pyrrolo[1,2-a]indol-4-ylmethyl)-N-methyl-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide

HRID 90467Notes

Reaction equation

HRID 90467 reaction equation
[CH2:1]([Cl:2])[CH2:3][Cl:4].[CH3:22][NH:23][CH2:24][c:25]1[c:26]2[n:27]([c:28]3[cH:29][cH:30][cH:31][cH:32][c:33]13)[CH2:34][CH2:35][CH2:36]2.[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[ClH:5].[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[O:6]=[C:7]1[CH2:8][CH2:9][c:10]2[cH:11][c:12]([CH:17]=[CH:18][C:19](=[O:20])[OH:21])[cH:13][n:14][c:15]2[NH:16]1.[OH2:47].[OH2:60].[OH:37][n:38]1[c:39]2[c:40]([cH:41][cH:42][cH:43][cH:44]2)[n:45][n:46]1>>[O:6]=[C:7]1[CH2:8][CH2:9][c:10]2[cH:11][c:12]([CH:17]=[CH:18][C:19](=[O:21])[N:23]([CH3:22])[CH2:24][c:25]3[c:26]4[n:27]([c:28]5[cH:29][cH:30][cH:31][cH:32][c:33]35)[CH2:34][CH2:35][CH2:36]4)[cH:13][n:14][c:15]2[NH:16]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 962Water2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 221390482,3-dihydro-8-(methylaminomethyl)-1H-3a-azacyclopenta[a]indeneHCID 66905303(E)-3-(7-oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid

Product 1

HCID 66780822N-(2,3-dihydro-1H-pyrrolo[1,2-a]indol-4-ylmethyl)-N-methyl-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide

Sources & evidence

ORD record
ord-d3de4cb04af0439091e0b2743c3a0cca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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