Triethylamine → HCID 57699402, compound

HRID 905703Notes

Reaction equation

HRID 905703 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[CH:7][S:6][C:5]1=[N:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=1.C([N:31]([CH2:34]C)CC)C.ClC(OC1C=CC([N+]([O-])=O)=CC=1)=[O:38].O.N>C1COCC1>[F:28][C:24]1[CH:23]=[C:22]([N:21]=[C:5]2[N:4]([CH2:3][CH2:2][NH:1][C:34]([NH2:31])=[O:38])[C:8]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[CH:11][CH:10]=3)=[CH:7][S:6]2)[CH:27]=[CH:26][CH:25]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 821294-Nitrophenyl chloroformateHCID 12896473Azane;hydrateHCID 67407252HCID 67407252, compound

Product 1

HCID 57699402HCID 57699402, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N-[3-(2-aminoethyl)-4-(4-morpholinophenyl)thiazol-2(3H)-ylidene]-3-fluoroaniline obtained in Example 1 was dissolved in THF, and thereto was added triethylamine, and then thereto was added 4-nitrophenyl chloroformate under ice-cooling. The mixture was stirred for 2 hours. Thereto was added ammonia water, and the mixture was stirred for 2 hours at room temperature. The resulting compound was recrystallized from methanol to give the titled compound.

Workup

  1. temperaturecooling
  2. stirringthe mixture was stirred for 2 hours at room temperature
  3. customThe resulting compound was recrystallized from methanol

Sources & evidence

ORD record
ord-59e3768a14e341629881f1fdad25d2e6
Source dataset
uspto-grants-2011_09
Patent number
US08012971B2

Reaction notes

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