反应详情

温度

0 °C

Ammonium tetrafluoroborate (20.97 g, 200 mmol) was dissolved in aqueous acetic acid (500 mL AcOH/250 mL water) and cooled to 0° C. 4-Bromo-2-methyl aniline (compound 1f, 18.61 g, 100 mmol) and 42 mL of aqueous concentrated HCl (36% w/w, 12N, 500 mmol) were sequentially added. The mixture was stirred for 20 minutes at 0° C., and then NaNO2 (7.59 g, 110 mmol) was added. The reaction was stirred for 1 hour at 0° C. and warmed to room temperature. After 16 hours at room temperature, the mixture was concentrated under reduced pressure and the residue was azeotroped with toluene and dried under high vacuum. The solid was suspended in 500 mL of CHCl3 and KOAc (12.76 g, 130 mmol) and 18-crown-6 (7.93 g, 30 mmol) were added. The reaction was stirred for 1.5 hours at room temperature. The mixture was washed with water, dried over anhydrous MgSO4, filtered through Celite and concentrated under reduced pressure to provide 30 g of 5-bromo-1H-indazole (2f) as a tan solid. The crude material was used without further purification.

1. stirringThe reaction was stirred for 1 hour at 0° C.
2. temperaturewarmed to room temperature
3. waitAfter 16 hours at room temperature
4. concentrationthe mixture was concentrated under reduced pressure
5. customthe residue was azeotroped with toluene
6. customdried under high vacuum
7. stirringThe reaction was stirred for 1.5 hours at room temperature
8. washThe mixture was washed with water
9. dry with materialdried over anhydrous MgSO4
10. filtrationfiltered through Celite
11. concentrationconcentrated under reduced pressure