Hydrochloric Acid → HCID 16735147, compound

HRID 910211Notes

Reaction equation

HRID 910211 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.C(N)(=[S:21])C.Cl>CN(C)C=O>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([C:15](=[S:21])[NH2:16])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2723949ThioacetamideHCID 67405072HCID 67405072, compound

Product 1

HCID 16735147HCID 16735147, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

4-(6-Iodoimidazo[1,2-a]pyridin-2-yl)benzonitrile (345 mg) and thioacetamide (150 mg) were added to a saturated solution (5 mL) of hydrogen chloride in dimethylformamide. The mixture was heated at 80° C. for 4 hours, and the solvent was evaporated. Saturated sodium hydrogencarbonate was added to the residue, followed by recovering the solid through filtration and drying, to thereby yield the title compound (269 mg).

Workup

  1. customthe solvent was evaporated
  2. additionSaturated sodium hydrogencarbonate was added to the residue
  3. customby recovering the solid
  4. filtrationthrough filtration
  5. customdrying

Sources & evidence

ORD record
ord-06284ed182af41f697f41bf1297866e0
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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