Morpholine → HCID 67951154, compound

HRID 923654Notes

Reaction equation

HRID 923654 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[S:9][N:10]=[C:11]([O:12][CH2:13][C:14]([OH:16])=O)[C:3]=12.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.CCN=C=NCCCN(C)C.CCN(C(C)C)C(C)C>CN(C1C=CN=CC=1)C>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[S:9][N:10]=[C:11]([O:12][CH2:13][C:14]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[C:3]=12

Participants

6

Reactant 4

HCID 8083MorpholineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 67951152HCID 67951152, compound

Product 1

HCID 67951154HCID 67951154, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Alternatively, the coupling reaction of acid 26 with morpholine in the presence of EDCI, DMAP and DIEA, by a procedure similar to that for compound 21 (YMU1), gave compound 27 in 82% yield.

Sources & evidence

ORD record
ord-18e5598de85940bda1710ee2485c3bbd
Source dataset
uspto-grants-2016_03
Patent number
US09278982B2

Reaction notes

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