Potassium Carbonate → HCID 66558345, compound

HRID 925415Notes

Reaction equation

HRID 925415 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][N:13]=[C:12](S(C)(=O)=O)[N:11]=2)=[CH:8][C:7]([C:20]([NH2:22])=[O:21])=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[N:23]1([C:29]2[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=2)[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([O:35][C:32]3[CH:31]=[CH:30][C:29]([N:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)=[CH:34][CH:33]=3)[N:11]=2)=[CH:8][C:7]([C:20]([NH2:22])=[O:21])=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 92467p-(1-Piperazinyl)phenolHCID 70873498HCID 70873498, compound

Product 1

HCID 66558345HCID 66558345, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

50 mg (0.155 mmol) of 1-tert-butyl-5-[2-(methylsulfonyl)pyrimidin-4-yl]-1H-pyrazole-3-carboxamide were dissolved in 1.5 mL of dry DMF; then, 30 mg (0.17 mmol) of 4-piperazin-1-yl-phenol and 64 mg (0.464 mmol) of potassium carbonate were added. The final suspension was stirred at 70° C. for 1 h then the final mixture was purified by preparative HPLC/MS to provide the title compound (20%).

Workup

  1. customthe final mixture was purified by preparative HPLC/MS

Sources & evidence

ORD record
ord-993e4567325d48bab373b4ff28c71f4a
Source dataset
uspto-grants-2016_03
Patent number
US09284298B2

Reaction notes

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