Sodium hydride → HCID 68000947, compound

HRID 932194Notes

Reaction equation

HRID 932194 reaction equation
[H-].[Na+].[I-].[CH3:4][S+](C)(C)=O.[Si:9]([O:26][CH2:27][C@@H:28]([N:31]1[C@H:36]([C:37]2[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][CH:38]=2)[C@@H:35]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([Cl:50])[CH:45]=2)[CH2:34][C@@:33](/[CH:52]=[CH:53]/[C:54]([O:56][CH3:57])=[O:55])([CH3:51])[C:32]1=[O:58])[CH2:29][CH3:30])([C:22]([CH3:25])([CH3:24])[CH3:23])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[S].[I-]>C1COCC1.CS(C)=O>[Si:9]([O:26][CH2:27][C@@H:28]([N:31]1[C@H:36]([C:37]2[CH:38]=[CH:39][C:40]([Cl:43])=[CH:41][CH:42]=2)[C@@H:35]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([Cl:50])[CH:45]=2)[CH2:34][C@@:33]([CH:52]2[CH2:4][CH:53]2[C:54]([O:56][CH3:57])=[O:55])([CH3:51])[C:32]1=[O:58])[CH2:29][CH3:30])([C:22]([CH3:25])([CH3:24])[CH3:23])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

8

Reactant 5

HCID 24758Sodium hydride3×HCID 30165Iodide IonHCID 74498Sulfoxonium, trimethyl-, iodide (1:1)2×HCID 5362487Sulfur4×HCID 67999277HCID 67999277, compound

Product 1

HCID 68000947HCID 68000947, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolvent3×HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of sodium hydride (12 mg, 0.30 mmol, 60% dispersion in oil) in THF (1.0 mL) under an argon atmosphere was added trimethylsulfoxonium iodide (72 mg, 0.33 mmol) portionwise over 1 minute. The reaction was stirred at rt for 1 hour. A solution of (E)-methyl 3-((3R,5R,6S)-1-((S)-1-(tert-butyldiphenylsilyloxy)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acrylate (120 mg, 0.165 mmol; Example 248, Step D) in DMSO (1.0 mL) was added dropwise over 1 minute. The reaction was stirred at rt overnight. After this time more sulfur ylide was synthesized by suspending trimethylsulfoxonium iodide (140 mg) in DMSO (0.5 mL) under a nitrogen atmosphere and treating the mixture with NaH (24 mg, 60% dispersion in oil) and stirring for 30 minutes. The sulfur ylide was then added to the reaction and the mixture was stirred at rt for 16 hours After this time more sulfur ylide was synthesized by suspending trimesulfoxonium iodide (140 mg) in DMSO (0.5 mL) under a nitrogen atmosphere and treating the mixture with NaH (24 mg, 60% dispersion in oil) and stirring for 30 minutes. The sulfur ylide was then added to the reaction and the mixture was stirred at rt for 16 hours. The reaction was partitioned between ethyl acetate (70 mL) and NH4Cl (30 mL, saturated aqueous solution). The separated organic layer was dried over MgSO4, filtered and evaporated in vacuo. Purification by reverse phase HPLC (Sunfire Prep C18 OBD 10 μm column, gradient elution of 40% MeCN in water to 100% MeCN in water over a 40 min period, where both solvents contain 0.1% TFA) gave the title compound as the first eluting and major diastereomer. Stereochemistry at the cyclopropane is a single but unassigned diastereomer. Mass Spectrum (ESI) m/z=742.2 (M+1).

Workup

  1. stirringThe reaction was stirred at rt overnight
  2. stirringstirring for 30 minutes
  3. customwas synthesized
  4. stirringstirring for 30 minutes
  5. stirringthe mixture was stirred at rt for 16 hours
  6. customThe reaction was partitioned between ethyl acetate (70 mL) and NH4Cl (30 mL, saturated aqueous solution)
  7. dry with materialThe separated organic layer was dried over MgSO4
  8. filtrationfiltered
  9. customevaporated in vacuo
  10. customPurification by reverse phase HPLC (Sunfire Prep
  11. washC18 OBD 10 μm column, gradient elution of 40% MeCN in water to 100% MeCN in water over a 40 min period, where both solvents

Sources & evidence

ORD record
ord-1b460598b2fd490b8ebe000ddb5a4313
Source dataset
uspto-grants-2016_03
Patent number
US09296736B2

Reaction notes

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