Bromide ion → 5-(4'-diethoxymethyl-biphenyl-2-yl)-2-(tetrahydropyran-2-yl)-2H-tetrazole

HRID 932826Notes

Reaction equation

HRID 932826 reaction equation
[Br-:42].[CH2:43]([CH3:44])[O:45][CH:46]([c:47]1[cH:48][cH:49][c:50]([Mg+:53])[cH:51][cH:52]1)[O:54][CH2:55][CH3:56].[CH3:57][O:58][C:59]([CH3:60])([CH3:61])[CH3:62].[Cl-:63].[Cl-:65].[Cl:24][c:25]1[cH:26][cH:27][cH:28][cH:29][c:30]1-[c:31]1[n:32]([CH:33]2[CH2:34][CH2:35][CH2:36][CH2:37][O:38]2)[n:39][n:40][n:41]1.[Cl:6][c:7]1[c:8](-[c:13]2[n:14][n:15][n:16]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[n:17]2)[cH:9][cH:10][cH:11][cH:12]1.[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1.[Zn+2:64]>>[c:7]1(-[c:50]2[cH:49][cH:48][c:47]([CH:46]([O:45][CH2:43][CH3:44])[O:54][CH2:55][CH3:56])[cH:52][cH:51]2)[c:8](-[c:13]2[n:14][n:15][n:16]([CH:18]3[O:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[n:17]2)[cH:9][cH:10][cH:11][cH:12]1

Participants

9

Reactant 8

HCID 259Bromide ionHCID 312Chloride2×HCID 8028TetrahydrofuranHCID 15413tert-Butyl methyl etherHCID 32051Zinc(2+)HCID 675464055-(2-chlorophenyl)-1-(tetrahydropyran-2-yl)-1H-tetrazoleHCID 675468845-(2-Chlorophenyl)-2-(oxan-2-yl)-2H-tetrazoleHCID 178470949HCID 178470949, compound

Product 1

HCID 586182215-(4'-diethoxymethyl-biphenyl-2-yl)-2-(tetrahydropyran-2-yl)-2H-tetrazole

Sources & evidence

ORD record
ord-e747c6ec67f44c038ef131ac6883554e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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