Hydrochloric Acid → 1-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)-2-methylpropan-1-one

HRID 933024Notes

Reaction equation

HRID 933024 reaction equation
[CH3:25][CH:26]([CH3:27])[C:28]([OH:29])=[O:30].[CH3:42][N:43]([CH3:44])[CH2:45][CH2:46][CH2:47][N:48]=[C:49]=[N:50][CH2:51][CH3:52].[CH3:62][N:63]([CH3:64])[CH:65]=[O:66].[CH:53]([N:54]([CH:55]([CH3:56])[CH3:57])[CH2:58][CH3:59])([CH3:60])[CH3:61].[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][CH:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1)[n:11]2.[ClH:41].[OH:31][n:32]1[c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]2[n:39][n:40]1>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][CH:13]1[CH2:14][CH2:15][N:16]([C:28]([CH:26]([CH3:25])[CH3:27])=[O:29])[CH2:17][CH2:18]1)[n:11]2

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6590Isobutyric AcidHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 584049524-(2-Chloro-6-(piperidin-4-ylmethyl)pyrido[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 584049791-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-1-yl)-2-methylpropan-1-one

Sources & evidence

ORD record
ord-f569ae6656b24f54a99ca9a41aa2f5fe
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…