Water → 2-Methyl-5-trimethylsilanylethynyl-thiazole-4-carbonitrile

HRID 933934Notes

Reaction equation

HRID 933934 reaction equation
[Br:1][c:2]1[c:3]([C:8]#[N:9])[n:4][c:5]([CH3:7])[s:6]1.[CH2:35]([N:36]([CH2:37][CH3:38])[CH2:39][CH3:40])[CH3:41].[CH3:10][Si:11]([CH3:12])([CH3:13])[C:14]#[CH:15].[Cu:43][I:44].[OH2:42].[c:16]1([P:17]([c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[cH:30][cH:31][cH:32][cH:33][cH:34]1>>[c:2]1([C:15]#[C:14][Si:11]([CH3:10])([CH3:12])[CH3:13])[c:3]([C:8]#[N:9])[n:4][c:5]([CH3:7])[s:6]1

Participants

7

Reactant 6

HCID 962WaterHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 8493835-Bromo-2-methylthiazole-4-carbonitrile

Product 1

HCID 685385072-Methyl-5-trimethylsilanylethynyl-thiazole-4-carbonitrile

Sources & evidence

ORD record
ord-848839d1f1bf4775bbcc26d39ee6183f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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