Chloride → 4-(3-Fluoropyrazin-2-YL)tetrahydro-2H-pyran-4-OL
Reaction equation
[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[CH:12]([Mg+:13])([CH3:14])[CH3:15].[Cl-:11].[Cl-:9].[F:1][c:2]1[n:3][cH:4][cH:5][n:6][c:7]1[I:8].[Li+:10].[O:16]1[CH2:17][CH2:18][C:19](=[O:22])[CH2:20][CH2:21]1>>[F:1][c:2]1[n:3][cH:4][cH:5][n:6][c:7]1[C:19]1([OH:22])[CH2:18][CH2:17][O:16][CH2:21][CH2:20]1Participants
7
Sources & evidence
- ORD record
- ord-4acc30233cf942bf970285c3e3d616e0
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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