Hydrochloric Acid → 4-(4-Bromo-2-chlorophenylamino)-5,6-dichloronicotinic acid

HRID 937099Notes

Reaction equation

HRID 937099 reaction equation
[Br:11][c:12]1[cH:13][c:14]([Cl:19])[c:15]([NH2:18])[cH:16][cH:17]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:2][Si:3]([N-:4][Si:5]([CH3:6])([CH3:7])[CH3:8])([CH3:9])[CH3:10].[CH3:38][CH2:39][O:40][C:41](=[O:42])[CH3:43].[Cl:20][c:21]1[c:22]([Cl:31])[c:23]([Cl:30])[n:24][cH:25][c:26]1[C:27](=[O:28])[OH:29].[ClH:37].[Li+:1]>>[Br:11][c:12]1[cH:13][c:14]([Cl:19])[c:15]([NH:18][c:21]2[c:22]([Cl:31])[c:23]([Cl:30])[n:24][cH:25][c:26]2[C:27](=[O:28])[OH:29])[cH:16][cH:17]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 6101694-Bromo-2-chloroanilineHCID 3280088Npc316347HCID 115866384,5,6-Trichloronicotinic acid

Product 1

HCID 116612174-(4-Bromo-2-chlorophenylamino)-5,6-dichloronicotinic acid

Sources & evidence

ORD record
ord-09f2c78f22794aec8739394763093d75
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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