Tetrahydrofuran → 5-Nitro-3-trimethylsilanylethynyl-pyridin-2-ylamine

HRID 938492Notes

Reaction equation

HRID 938492 reaction equation
[CH3:12][Si:13]([CH3:14])([CH3:15])[C:16]#[CH:17].[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[Cu:30][I:31].[NH2:1][c:2]1[n:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[cH:6][c:7]1[Br:8].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[cH:6][c:7]1[C:17]#[C:16][Si:13]([CH3:12])([CH3:14])[CH3:15]

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 27344122-Amino-3-bromo-5-nitropyridine

Product 1

HCID 115287895-Nitro-3-trimethylsilanylethynyl-pyridin-2-ylamine

Sources & evidence

ORD record
ord-68bcbba13a3a494d895f8540999b62e7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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