Triethylamine → 1-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole

HRID 938570Notes

Reaction equation

HRID 938570 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:14])[c:5]([CH2:6][n:7]2[cH:8][n:9][cH:10][cH:11]2)[cH:12][cH:13]1.[CH3:15][Si:16]([CH3:17])([CH3:18])[C:19]#[CH:20].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[Cu:28][I:29].[Pd:30]([Cl:31])[Cl:32].[c:33]1([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[cH:47][cH:48][cH:49][cH:50][cH:51]1.[c:52]1([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[c:2]1([C:20]#[C:19][Si:16]([CH3:15])([CH3:17])[CH3:18])[cH:3][c:4]([CH3:14])[c:5]([CH2:6][n:7]2[cH:8][n:9][cH:10][cH:11]2)[cH:12][cH:13]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 225688221-(4-Bromo-2-methyl-benzyl)-1H-imidazole

Product 1

HCID 225689641-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole

Sources & evidence

ORD record
ord-0310da660ba242128eb78cc52cb9163f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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