Sodium ion → tert-Butyl 4-(hydroxymethyl)-4-(pyridin-4-yl)piperidine-1-carboxylate

HRID 939638Notes

Reaction equation

HRID 939638 reaction equation
[Al+3:26].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27].[Na+:32].[Na+:33].[Na+:34].[O-:35][S:36](=[O:37])(=[O:38])[O-:39].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1.[OH-:31].[OH2:51].[n:1]1[cH:2][cH:3][c:4]([C:7]2([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:5][cH:6]1>>[n:1]1[cH:2][cH:3][c:4]([C:7]2([CH2:20][OH:21])[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:5][cH:6]1

Participants

11

Reactant 10

HCID 923Sodium ion3×HCID 961HydroxideHCID 962WaterHCID 1117Sulfate IonHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 589936931-tert-Butyl 4-ethyl 4-(pyridin-4-yl)piperidine-1,4-dicarboxylate

Product 1

HCID 58993619tert-Butyl 4-(hydroxymethyl)-4-(pyridin-4-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-46375a700f3b4c6fae83276e87b4c1b9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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