Dimethylformamide → N-[4-chloro-5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-3-(1-cyano-1-methylethyl)benzamide

HRID 941049Notes

Reaction equation

HRID 941049 reaction equation
[C:1](#[N:2])[C:3]([CH3:4])([CH3:5])[c:6]1[cH:7][c:8]([C:9](=[O:10])[OH:11])[cH:12][cH:13][cH:14]1.[CH3:21][N:22]([CH3:23])[CH:24]=[O:25].[CH3:51][N:52]1[CH2:53][CH2:54][CH2:55][C:56]1=[O:57].[Cl:15][C:16]([C:17]([Cl:18])=[O:19])=[O:20].[NH2:26][c:27]1[c:28]([F:50])[cH:29][c:30]([Cl:49])[c:31]([O:32][c:33]2[cH:34][cH:35][c:36]3[n:37]([n:38]2)[cH:39][c:40]([NH:42][C:43](=[O:44])[CH:45]2[CH2:46][CH2:47]2)[n:41]3)[cH:48]1.[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1>>[C:1](#[N:2])[C:3]([CH3:4])([CH3:5])[c:6]1[cH:7][c:8]([C:9](=[O:11])[NH:26][c:27]2[c:28]([F:50])[cH:29][c:30]([Cl:49])[c:31]([O:32][c:33]3[cH:34][cH:35][c:36]4[n:37]([n:38]3)[cH:39][c:40]([NH:42][C:43](=[O:44])[CH:45]3[CH2:46][CH2:47]3)[n:41]4)[cH:48]2)[cH:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 13387N-methyl-2-pyrrolidoneHCID 65578Oxalyl chlorideHCID 571495383-(2-Cyanopropan-2-yl)benzoic acidHCID 57505449N-[6-(3-amino-6-chloro-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

Product 1

HCID 57505690N-[4-chloro-5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-3-(1-cyano-1-methylethyl)benzamide

Sources & evidence

ORD record
ord-43c47583556b4d668be707a85fa34b5f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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