Tetrahydrofuran → Thiazole, 2-[(trimethylsilyl)ethynyl]-

HRID 94134Notes

Reaction equation

[Br:1][c:2]1[s:3][cH:4][cH:5][n:6]1.[C:7](#[CH:8])[Si:9]([CH3:10])([CH3:11])[CH3:12].[CH2:13]1[O:14][CH2:15][CH2:16][CH2:17]1.[Cu:59][I:60].[Pd:18]([Cl:19])[Cl:20].[c:21]1([P:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1.[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[c:2]1([C:8]#[C:7][Si:9]([CH3:10])([CH3:11])[CH3:12])[s:3][cH:4][cH:5][n:6]1

Participants

Reactant 6

HCID 8028Tetrahydrofuran

HCID 11776Triphenylphosphine2×

HCID 24290Palladium Chloride

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 764302-Bromothiazole

Product 1

HCID 11622446Thiazole, 2-[(trimethylsilyl)ethynyl]-

Sources & evidence

ORD record: ord-cab443443afc4074bb8990ae02b9208f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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