Dimethylformamide → 2-(5-Methoxy-pent-1-yn-1-yl)-benzenesulfonamide

HRID 941640Notes

Reaction equation

HRID 941640 reaction equation
[CH2:17]([CH2:18][CH2:19][C:20]#[CH:21])[O:22][CH3:23].[CH3:1][N:2]([CH3:3])[CH:4]=[O:5].[CH3:67][CH2:68][N:69]([CH2:70][CH3:71])[CH2:72][CH3:73].[Cu:24][I:25].[I:6][c:7]1[c:8]([S:13](=[O:14])(=[O:15])[NH2:16])[cH:9][cH:10][cH:11][cH:12]1.[Pd:26]([Cl:27])[Cl:28].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1.[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1>>[c:7]1([C:21]#[C:20][CH2:19][CH2:18][CH2:17][O:22][CH3:23])[c:8]([S:13](=[O:14])(=[O:15])[NH2:16])[cH:9][cH:10][cH:11][cH:12]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28248922-Iodobenzene-1-sulfonamideHCID 142211075-Methoxypent-1-yne

Product 1

HCID 197936262-(5-Methoxy-pent-1-yn-1-yl)-benzenesulfonamide

Sources & evidence

ORD record
ord-c02ec75bacc74755a48bd7ef05985de1
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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