Hydrochloric Acid → 4-chloro-N-methoxy-N-methylbenzo[b]thiophene-2-carboxamide

HRID 942021Notes

Reaction equation

HRID 942021 reaction equation
[CH3:20][N:21]([CH3:22])[CH:23]=[O:24].[CH3:26][NH:27][O:28][CH3:29].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:30][CH2:31][Cl:32].[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[s:13][c:14]([C:17](=[O:18])[OH:19])[cH:15][c:16]12.[ClH:25].[OH2:33]>>[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[s:13][c:14]([C:17](=[O:19])[N:27]([CH3:26])[O:28][CH3:29])[cH:15][c:16]12

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 14232N,O-DimethylhydroxylamineHCID 65578Oxalyl chlorideHCID 38545164-Chlorobenzo(b)thiophene-2-carboxylic Acid

Product 1

HCID 224738924-chloro-N-methoxy-N-methylbenzo[b]thiophene-2-carboxamide

Sources & evidence

ORD record
ord-3302d10a47ed45bca3154c3c34ea398b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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